Disitertide

Research use only, not for human use.

Disitertide (P144) is a TGF-β1 antagonist peptide.

Disitertide (P144) is a TGF-β1 antagonist peptide; induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and an upregulation of SMAD7 at both transcriptional and translational levels; active in vivo.Brain Cancer Phase 2 Clinical

Disitertide (P144, 100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells. Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.Disitertide (10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.Western Blot AnalysisCell Line:Mouse embryo osteoblast precursor MC3T3-E1 cells Concentration:100 μg/mL Incubation Time:4 h Result:Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment. Animal Model:Human hypertrophic scars were implanted in 60 nude mice. Dosage:300 μg/mL was added the Lipogel.Administration:Topical application daily administered.Result:Successful shedding was achieved in 83,3% of the xenografts.

P144 | P144 Peptide

TGF-beta/Smad

TGFBR

TGFBR

Cancer

Brain Cancer

272105-42-7

1580.824

C68H109N17O22S2

>98% (HPLC)

DMSO

CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C(C)O)N

L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-

(-20℃)

With Ice Pack

≥ 2 years