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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - L82-G17

L82-G17

CAS No. 92285-87-5

L82-G17( —— )

Catalog No. M28986 CAS No. 92285-87-5

L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L82-G17
  • Note
    Research use only, not for human use.
  • Brief Description
    L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
  • Description
    L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
  • In Vitro
    L82-G17 (200 μM, 30 min) has selective uncompetitive inhibitory effect for LigI. L82-G17 (0-100 μM) increases LigI binding to non-ligatable nicked DNA binding.L82-G17 inhibits step 3 of the ligation reaction, phosphodiester bond formation.L82-G17 (0-100 μM) inhibits DNA synthesis, cell viability and s induces DNA damage. Cell Viability Assay Cell Line:HeLa cells Concentration:0-30 μM Incubation Time:5 days Result:Reduced cell number by about 70% at 20 μM.Cell Proliferation Assay Cell Line:CH12F3 WT and CH12F3Δ/Δ cells Concentration:0-100 μM Incubation Time:72 h Result:Had great effect on the proliferation and survival of the parental CH12F3 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    FGFR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    92285-87-5
  • Formula Weight
    264.67
  • Molecular Formula
    C11H9ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (472.29 mM)
  • SMILES
    OC1=CC=CC(\C=N\NC2=C(Cl)C(=O)NN=C2)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lescarbeau, Andre, et al. Preparation of substituted pyrrolopyrimidines as FGFR inhibitors and methods of making and using the same. WO2022109577.
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