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Kenpaullone
CAS No. 142273-20-9
Kenpaullone ( 9-Bromopaullone;NSC-664704 )
Catalog No. M11777 CAS No. 142273-20-9
Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 178 | In Stock |
|
| 50MG | 302 | In Stock |
|
| 100MG | 448 | In Stock |
|
| 500MG | 1017 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKenpaullone
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NoteResearch use only, not for human use.
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Brief DescriptionKenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
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DescriptionKenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM); shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM; displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.
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Synonyms9-Bromopaullone;NSC-664704
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p35;GSK-3β
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number142273-20-9
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Formula Weight327.18
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Molecular FormulaC16H11BrN2O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 35 mg/mL
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SMILESO=C(NC1=CC=CC=C12)CC3=C2NC4=C3C=C(Br)C=C4
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Chemical NameIndolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zaharevitz DW, et al. Cancer Res. 1999 Jun 1;59(11):2566-9.
2. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
3. Bain J, et al. Biochem J. 2003 Apr 1;371(Pt 1):199-204.
4. Lyssiotis CA, et al. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
2. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
3. Bain J, et al. Biochem J. 2003 Apr 1;371(Pt 1):199-204.
4. Lyssiotis CA, et al. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
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