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Kenpaullone

CAS No. 142273-20-9

Kenpaullone ( 9-Bromopaullone;NSC-664704 )

Catalog No. M11777 CAS No. 142273-20-9

Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Kenpaullone
  • Note
    Research use only, not for human use.
  • Brief Description
    Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
  • Description
    Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM); shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM; displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.
  • Synonyms
    9-Bromopaullone;NSC-664704
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p35;GSK-3β
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    142273-20-9
  • Formula Weight
    327.18
  • Molecular Formula
    C16H11BrN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    O=C(NC1=CC=CC=C12)CC3=C2NC4=C3C=C(Br)C=C4
  • Chemical Name
    Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zaharevitz DW, et al. Cancer Res. 1999 Jun 1;59(11):2566-9.
2. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
3. Bain J, et al. Biochem J. 2003 Apr 1;371(Pt 1):199-204.
4. Lyssiotis CA, et al. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
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