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NG-52
CAS No. 212779-48-1
NG-52( Compound 52 )
Catalog No. M13385 CAS No. 212779-48-1
NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 88 | In Stock |
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| 5MG | 144 | In Stock |
|
| 10MG | 255 | In Stock |
|
| 25MG | 489 | In Stock |
|
| 50MG | 705 | In Stock |
|
| 100MG | 981 | In Stock |
|
| 500MG | 1971 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNG-52
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NoteResearch use only, not for human use.
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Brief DescriptionNG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase.
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DescriptionNG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM).
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In VitroCell Proliferation Assay Cell Line:Glioma U87 and U251 cells Concentration:0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time:6 days Result:Potently inhibited the proliferation of primary glioma cells.Western Blot Analysis Cell Line:Glioma U87 and U251 cells Concentration:0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time:12 hours or 24 hours Result:Potently inhibited the proliferation of primary glioma cells.
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In VivoAnimal Model:Female nu/nu mice (5-week-old) injected with glioma cells Dosage:50 mg/kg, 100 mg/kg, 150 mg/kg Administration:Oral administration; daily; for 13 daysResult:Dose-dependently suppressed the growth of glioma xenograft.
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SynonymsCompound 52
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PathwayAngiogenesis
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TargetCDK
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RecptorCdc28p
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number212779-48-1
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Formula Weight346.81
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Molecular FormulaC16H19ClN6O
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Purity>98% (HPLC)
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SolubilityDMSO: > 100mM
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SMILESCC(C)N1C2=NC(NCCO)=NC(NC3=CC=CC(Cl)=C3)=C2N=C1
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Chemical Name2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)ethan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.ray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
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