IIIM-290

CAS No. 2213468-64-3

IIIM-290 ( IIIM290 )

Catalog No. M13528 CAS No. 2213468-64-3

IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1143 Get Quote
50MG 2322 Get Quote
100MG 3060 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    IIIM-290
  • Note
    Research use only, not for human use.
  • Brief Description
    IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
  • Description
    IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively; selectively inhibits Molt-4/MIAPaCa-2 cell growth with GI50 of <1 uM; inhibits the cell growth of MIAPaCa-2 cells via caspase-dependent apoptosis, demonstrates in vivo efficacy in pancreatic, colon, and leukemia xenografts at 50 mg/kg, po., without CYP/efflux-pump liability, and mutagenic/genotoxic or cardiotoxic effects.
  • Synonyms
    IIIM290
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2213468-64-3
  • Formula Weight
    462.32
  • Molecular Formula
    C23H21Cl2NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1
  • Chemical Name
    (1'R,2'S)-2-(2,6-Dichlorostyryl)-5,7-dihydroxy-8-(3-hydroxy-1- methylpiperidin-4-yl)-4H-chromen-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bharate SB, et al. J Med Chem. 2018 Feb 22;61(4):1664-1687.
molnova catalog
related products
  • BS-181 hydrochloride

    BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM.

  • 1NM-PP1

    1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).

  • Purvalanol B

    A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.