IIIM-290( IIIM290 )

Catalog No. M13528 CAS No. 2213468-64-3

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HNMR

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Product Name

IIIM-290
Note

Research use only, not for human use.
Brief Description

IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
Description

IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively; selectively inhibits Molt-4/MIAPaCa-2 cell growth with GI50 of <1 uM; inhibits the cell growth of MIAPaCa-2 cells via caspase-dependent apoptosis, demonstrates in vivo efficacy in pancreatic, colon, and leukemia xenografts at 50 mg/kg, po., without CYP/efflux-pump liability, and mutagenic/genotoxic or cardiotoxic effects.
In Vitro

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In Vivo

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Synonyms

IIIM290
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

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Indication

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CAS Number

2213468-64-3
Formula Weight

462.323
Molecular Formula

C23H21Cl2NO5
Purity

>98% (HPLC)
Solubility

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SMILES

OC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1
Chemical Name

(1'R,2'S)-2-(2,6-Dichlorostyryl)-5,7-dihydroxy-8-(3-hydroxy-1- methylpiperidin-4-yl)-4H-chromen-4-one

1. Bharate SB, et al. J Med Chem. 2018 Feb 22;61(4):1664-1687.

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