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JQ1
CAS No. 1268524-70-4
JQ1 ( JQ-1;(+)-JQ-1 )
Catalog No. M11126 CAS No. 1268524-70-4
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 87 | In Stock |
|
| 50MG | 132 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJQ1
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NoteResearch use only, not for human use.
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Brief Description(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
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Description(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.
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SynonymsJQ-1;(+)-JQ-1
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBRD4(1);BRD4(2)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1268524-70-4
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Formula Weight456.99
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Molecular FormulaC23H25ClN4O2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 45 mg/mL
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SMILESO=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
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Chemical Name6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.
4. Tgel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.
4. Tgel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
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JQ1
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
