BAY-850
CAS No. 2099142-76-2
BAY-850 ( BAY 850;BAY850 )
Catalog No. M13325 CAS No. 2099142-76-2
BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBAY-850
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
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DescriptionBAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay; shows no inhibitory activity in a panel of 354 kinases and only modest effects on a few GPCRs; displaces a tetra-acetylated H4 peptide with an IC50 of 22 nM, and the tetra-acetylated peptides with IC50 of 115 nM; pecifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells.
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SynonymsBAY 850;BAY850
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2099142-76-2
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Formula Weight654.25
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Molecular FormulaC38H44ClN5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N[C@H](CC1=CC=C(C#N)C=C1)CNC2CCC(N)CC2)C3=CC(C4=CC=C(CN[C@@H](C5=CC=C(C)C=C5)C)O4)=C(OC)C=C3Cl
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Chemical NameN-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5-((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fernández-Montalván AE, et al. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.
molnova catalog
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