IU1-47

CAS No. 670270-31-2

IU1-47 ( IU1-47; IU1 47; IU147 )

Catalog No. M15562 CAS No. 670270-31-2

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 67 Get Quote
5MG 110 Get Quote
10MG 170 Get Quote
25MG 349 Get Quote
50MG 519 Get Quote
100MG 743 Get Quote
500MG 1512 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    IU1-47
  • Note
    Research use only, not for human use.
  • Brief Description
    IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.
  • Description
    IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
  • Synonyms
    IU1-47; IU1 47; IU147
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    670270-31-2
  • Formula Weight
    330.86
  • Molecular Formula
    C19H23ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 16.67 mg/mL 50.39 mM
  • SMILES
    CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
  • Chemical Name
    1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
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