IU1-47
CAS No. 670270-31-2
IU1-47 ( IU1-47; IU1 47; IU147 )
Catalog No. M15562 CAS No. 670270-31-2
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 67 | Get Quote |
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5MG | 110 | Get Quote |
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10MG | 170 | Get Quote |
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25MG | 349 | Get Quote |
|
50MG | 519 | Get Quote |
|
100MG | 743 | Get Quote |
|
500MG | 1512 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameIU1-47
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NoteResearch use only, not for human use.
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Brief DescriptionIU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.
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DescriptionIU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
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SynonymsIU1-47; IU1 47; IU147
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number670270-31-2
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Formula Weight330.86
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Molecular FormulaC19H23ClN2O
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Purity>98% (HPLC)
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SolubilityDMSO : 16.67 mg/mL 50.39 mM
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SMILESCC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
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Chemical Name1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
molnova catalog
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