B-AP15 ( b-AP15;USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. )

Catalog No. M10064 CAS No. 1009817-63-3

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Product Name

B-AP15
Note

Research use only, not for human use.
Brief Description

B-AP15(NSC687852) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 of the 26S proteasome.
Description

B-AP15(NSC687852) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome.
Synonyms

b-AP15;USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852.
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

UCH-L5
Research Area

Cancer
Indication

——

CAS Number

1009817-63-3
Formula Weight

419.39
Molecular Formula

C22H17N3O6
Purity

>98%(HPLC)
Solubility

DMSO: 48 mg/mL warmed (114.45 mM)
SMILES

O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
Chemical Name

(3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one.

1. D'Arcy P, et al. Nat Med. 2011 Nov 6;17(12):1636-40.

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