GNE-6776 ( GNE6776;GNE 6776 )

Catalog No. M13135 CAS No. 2009273-71-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

GNE-6776
Note

Research use only, not for human use.
Brief Description

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
Description

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM ; dislpalys selectivity over USP47 and USP5 (>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents; promotes on-target pathway modulation in human xenografts.
Synonyms

GNE6776;GNE 6776
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

USP7
Research Area

——
Indication

——

CAS Number

2009273-71-4
Formula Weight

348.41
Molecular Formula

C20H20N4O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥310 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CCC1=C(C(=NC=C1C2=CN=C(C=C2)C(=O)NC)N)C3=CC=C(C=C3)O
Chemical Name

5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2carboxamide

1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.

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