Cart
sales@molnova.com
HS-38
CAS No. 1030203-81-6
HS-38( HS38 )
Catalog No. M10146 CAS No. 1030203-81-6
HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 60 | In Stock |
|
| 25MG | 124 | In Stock |
|
| 50MG | 200 | In Stock |
|
| 100MG | 325 | In Stock |
|
| 200MG | 484 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameHS-38
-
NoteResearch use only, not for human use.
-
Brief DescriptionHS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
-
DescriptionHS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR; decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation; also promotes relaxation in Ca(2+)-sensitized vessels.
-
In Vitro——
-
In Vivo——
-
SynonymsHS38
-
PathwayApoptosis
-
TargetDAPK
-
RecptorDAPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1030203-81-6
-
Formula Weight349.793
-
Molecular FormulaC14H12ClN5O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 7.14 mg/mL (20.41 mM)
-
SMILESCC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O
-
Chemical Name2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23.
2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17.
molnova catalog
related products
-
DAPK-IN-2
DAPK-IN-2 (WAY-380496) is a DAPK inhibitor. DAPK-IN-2 has potential anticancer activity, regulates autophagy and can be used to study cerebral infarction and ischemic diseases.
-
HS-38
HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
-
DRAK2-IN-16
DRAK2-IN-116 is a potent, selective DRAK2 inhibitor with IC50 of 3 nM.
