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HEC72702
CAS No. 1793063-59-8
HEC72702( HEC-72702 | HEC 72702 )
Catalog No. M12703 CAS No. 1793063-59-8
HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameHEC72702
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NoteResearch use only, not for human use.
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Brief DescriptionHEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
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DescriptionHEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM; displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM, demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.
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In Vitro——
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In VivoAnimal Model:6-7 weeks, 16-18 g, Female BALB/c mice(HDI mouse model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 7 days Result:Demonstrated a dose-dependent reduction of HBV DNA in the plasma of infected mice.
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SynonymsHEC-72702 | HEC 72702
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research Area——
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Indication——
Chemical Information
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CAS Number1793063-59-8
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Formula Weight581.457
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Molecular FormulaC24H26BrFN4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OCC)C1=C(NC(C2=NC=CS2)=N[C@H]1C3=C(Br)C=C(F)C=C3)CN4CCO[C@H](CCC(O)=O)C4
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Chemical Name3-((R)-4-(((R)-6-(2-Bromo-4- fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)- 3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374.
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