HDAC6-AR-IN-10

CAS No. 2042519-10-6

HDAC6-AR-IN-10 ( —— )

Catalog No. M13176 CAS No. 2042519-10-6

HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HDAC6-AR-IN-10
  • Note
    Research use only, not for human use.
  • Brief Description
    HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM.
  • Description
    HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM); inhibits AR signaling and reduces the AR protein levels in LNCaP cells; a useful tool compound in pharmacology studies to evaluate the value of dual inhibition of AR and HDAC6.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2042519-10-6
  • Formula Weight
    579.57
  • Molecular Formula
    C26H25F4N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jadhavar PS, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228.
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