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Apicidin

CAS No. 183506-66-3

Apicidin ( OSI 2040 )

Catalog No. M12833 CAS No. 183506-66-3

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Apicidin
  • Note
    Research use only, not for human use.
  • Brief Description
    Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
  • Description
    Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay; induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin; upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.
  • Synonyms
    OSI 2040
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    183506-66-3
  • Formula Weight
    623.78
  • Molecular Formula
    C34H49N5O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H](CCCCCC(CC)=O)C(N[C@@H](CC(N1OC)=CC2=C1C=CC=C2)C(N[C@H]3[C@H](C)CC)=O)=O)[C@](CCCC4)([H])N4C3=O
  • Chemical Name
    cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Darkin-Rattray SJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.
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