Cart
sales@molnova.com
Apicidin
CAS No. 183506-66-3
Apicidin( OSI 2040 )
Catalog No. M12833 CAS No. 183506-66-3
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameApicidin
-
NoteResearch use only, not for human use.
-
Brief DescriptionApicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
-
DescriptionApicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay; induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin; upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.
-
In Vitro——
-
In Vivo——
-
SynonymsOSI 2040
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number183506-66-3
-
Formula Weight623.78
-
Molecular FormulaC34H49N5O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (40.08 mM)
-
SMILESO=C(N[C@@H](CCCCCC(CC)=O)C(N[C@@H](CC(N1OC)=CC2=C1C=CC=C2)C(N[C@H]3[C@H](C)CC)=O)=O)[C@](CCCC4)([H])N4C3=O
-
Chemical Namecyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Darkin-Rattray SJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.
molnova catalog
related products
-
NCC-149
A potent and selective HDAC8 inhibitor with IC50 of 70 nM.
-
CUDC-101
A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
-
HDAC1,2-IN-2
A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.
