HNHA

Research use only, not for human use.

HNHA is an inhibitor of HDAC.

HNHA is an inhibitor of HDAC.(In Vitro):Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080). (In Vivo):Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo.

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Cell Cycle/DNA Damage

HDAC

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926908-04-5

303.4

C17H21NO2S

>98% (HPLC)

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ONC(=O)CCCCCCSc1ccc2ccccc2c1

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(-20℃)

With Ice Pack

≥ 2 years