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GSK840
CAS No. 2361146-30-5
GSK840( GSK'840 )
Catalog No. M26239 CAS No. 2361146-30-5
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | Get Quote |
|
| 10MG | 113 | Get Quote |
|
| 25MG | 177 | Get Quote |
|
| 50MG | 268 | Get Quote |
|
| 100MG | 401 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK840
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NoteResearch use only, not for human use.
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Brief DescriptionGSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
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DescriptionGSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).(In Vitro):In human HT-29 cells, GSK840 (0.01-3 μM) blocked TNF-induced necroptosis in a concentration-dependent manner. GSK840 binded the kinase domain and inhibited kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli.
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In VitroGSK840 (GSK'840)(0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.Cell Viability Assay Cell Line:Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM)Concentration:0.01-3 μM Incubation Time:24 hours Result:Blocked TNF-induced necroptosis in a concentration-dependent manner.
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In Vivo——
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SynonymsGSK'840
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PathwayApoptosis
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TargetRIP kinase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2361146-30-5
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Formula Weight365.433
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Molecular FormulaC21H23N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 110 mg/mL (301.02 mM)
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SMILESCNC(=O)c1ccc2n(cnc2c1)-c1ccc(CC(=O)OC(C)(C)C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kerwin BA. Polysorbates 20 and 80 used in the formulation of protein biotherapeutics:structure and degradation pathways. J Pharm Sci. 2008 Aug;97(8):2924-35.
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GSK840
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
