GSK-843

Research use only, not for human use.

GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation.

GSK-843 (3-10 μM; 18 h) induces apoptosis.GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis. Cell Viability Assay Cell Line:SVEC, L929, 3T3SA and mouse embryo fibroblast (MEF)Concentration:3 and 10 μM Incubation Time:18 hours Result:Decreased the cell viability of SVEC, L929, 3T3SA and MEF cells, and induced caspase activation followed by apoptotic cell death.Cell Viability Assa Cell Line:3T3-SA and SVEC4-10 cells Concentration:0.3, 1 and 3 μM Incubation Time:18 hours Result:Dose-dependently suppressed TNF-induced death and virus-induced necrosis to improved cell viability.

——

——

Apoptosis

RIP kinase

RIP kinase

——

——

1601496-05-2

377.49

C19H15N5S2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (132.45 mM; Ultrasonic )

Cc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1

——

(-20℃)

With Ice Pack

≥ 2 years