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RIPK2-IN-8

CAS No. 2141969-56-2

RIPK2-IN-8( RIPK2-IN-8 | RIPK2 IN 8 | RIPK2IN8 | RIPK2 inhibitor 8 )

Catalog No. M13424 CAS No. 2141969-56-2

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RIPK2-IN-8
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
  • Description
    A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM; displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel; effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM; significantly reverses MDP-induced pro-inflammatory cytokines in rat colon.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RIPK2-IN-8 | RIPK2 IN 8 | RIPK2IN8 | RIPK2 inhibitor 8
  • Pathway
    Apoptosis
  • Target
    RIP kinase
  • Recptor
    RIP kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2141969-56-2
  • Formula Weight
    392.449
  • Molecular Formula
    C18H21FN4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 31.25 mg/mL (79.63 mM)
  • SMILES
    NC1=NC(F)=CC(C2=CN=C3C=C(OCC)C(S(=O)(C(C)(C)C)=O)=CN32)=C1
  • Chemical Name
    4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.
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