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RIPK2-IN-8
CAS No. 2141969-56-2
RIPK2-IN-8( RIPK2-IN-8 | RIPK2 IN 8 | RIPK2IN8 | RIPK2 inhibitor 8 )
Catalog No. M13424 CAS No. 2141969-56-2
A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 337 | Get Quote |
|
| 50MG | 1674 | Get Quote |
|
| 100MG | 2538 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRIPK2-IN-8
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
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DescriptionA potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM; displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel; effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM; significantly reverses MDP-induced pro-inflammatory cytokines in rat colon.
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In Vitro——
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In Vivo——
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SynonymsRIPK2-IN-8 | RIPK2 IN 8 | RIPK2IN8 | RIPK2 inhibitor 8
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number2141969-56-2
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Formula Weight392.449
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Molecular FormulaC18H21FN4O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (79.63 mM)
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SMILESNC1=NC(F)=CC(C2=CN=C3C=C(OCC)C(S(=O)(C(C)(C)C)=O)=CN32)=C1
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Chemical Name4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.
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