RIPK2-IN-8 ( RIPK2-IN-8; RIPK2 IN 8; RIPK2IN8; RIPK2 inhibitor 8 )

Catalog No. M13424 CAS No. 2141969-56-2

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Datasheet

HNMR

HPLC

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Product Name

RIPK2-IN-8
Note

Research use only, not for human use.
Brief Description

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
Description

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM; displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel; effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM; significantly reverses MDP-induced pro-inflammatory cytokines in rat colon
Synonyms

RIPK2-IN-8; RIPK2 IN 8; RIPK2IN8; RIPK2 inhibitor 8
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

——
Indication

——

CAS Number

2141969-56-2
Formula Weight

392.45
Molecular Formula

C18H21FN4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

NC1=NC(F)=CC(C2=CN=C3C=C(OCC)C(S(=O)(C(C)(C)C)=O)=CN32)=C1
Chemical Name

4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine

1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.

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