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GNE-7883

CAS No. 2648450-42-2

GNE-7883( —— )

Catalog No. M37199 CAS No. 2648450-42-2

GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 179 Get Quote
5MG 282 Get Quote
10MG 455 Get Quote
25MG 808 Get Quote
50MG 1187 Get Quote
100MG 1782 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    GNE-7883
  • Note
    Research use only, not for human use.
  • Brief Description
    GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.
  • Description
    GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    YAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2648450-42-2
  • Formula Weight
    500.57
  • Molecular Formula
    C28H29FN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (199.77 mM; Ultrasonic )
  • SMILES
    O=C1C=C(NC2=C(C(=O)N3CC(CF)C3)C(=NN12)C=4N=CC=NC4C)C=5C=CC(=CC5)C6CCCCC6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.?
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