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Divarasib
CAS No. 2417987-45-0
Divarasib( —— )
Catalog No. M37705 CAS No. 2417987-45-0
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 581 | In Stock |
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| 10MG | 826 | In Stock |
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| 25MG | 1254 | In Stock |
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| 50MG | 1655 | In Stock |
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| 100MG | 2213 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDivarasib
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NoteResearch use only, not for human use.
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Brief DescriptionDivarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM.
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DescriptionDivarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.
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In Vitro——
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In VivoAnimal Model:Female C.B-17 SCID (Inbred) mice (20-21 weeks old; 24.1 g) with human NSCLC NCI-H2030.X1.1 cellsDosage:10, 25, or 100 mg/kg Administration:Oral gavage (PO) every day (QD) for 7 days (vehicle: 0.5% methylcellulose)Result:Decreased the ratio of free KRAS G12C to internal standard. Dose-dependent target engagement was observed for all time points (2, 8, and 24 h post-last dose), with over 90% KRAS G12C engagement observed for the highest dose 100 mg/kg assessed.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorKras
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Research Area——
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Indication——
Chemical Information
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CAS Number2417987-45-0
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Formula Weight622.06
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Molecular FormulaC29H32ClF4N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (160.76 mM; Ultrasonic )
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SMILESC[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lingyao Meng, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022 Sep 20;94(37):12927-12933.?
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