Enfuvirtide

Research use only, not for human use.

Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.

Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.(In Vitro):A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide.(In Vivo):Enfuvirtide has a T1/2 of 3.8 h.

Microbiology/Virology

HIV

HIV fusion

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159519-65-0

4491.9

C204H301N51O64

>98% (HPLC)

H2O : < 0.1 mg/mL (insoluble)

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(-20℃)

With Ice Pack

≥ 2 years