MUT-A( —— )

Catalog No. M12273 CAS No. 1591906-37-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MUT-A
Note

Research use only, not for human use.
Brief Description

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
Description

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively; interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM; inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM; impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
In Vitro

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In Vivo

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Synonyms

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Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

1591906-37-4
Formula Weight

413.576
Molecular Formula

C24H31NO3S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(S)-2-(tert-butoxy)-2-(4-(4,4-dimethylcyclohex-1-en-1-yl)-2-methyl-5-(pyridin-4-yl)thiophen-3-yl)acetic acid

1. Amadori C, et al. Retrovirology. 2017 Nov 9;14(1):50.

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