MUT-A

Research use only, not for human use.

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively; interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM; inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM; impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

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Microbiology/Virology

HIV

HIV

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1591906-37-4

413.576

C24H31NO3S

>98% (HPLC)

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(S)-2-(tert-butoxy)-2-(4-(4,4-dimethylcyclohex-1-en-1-yl)-2-methyl-5-(pyridin-4-yl)thiophen-3-yl)acetic acid

(-20℃)

With Ice Pack

≥ 2 years