Cart
sales@molnova.com
MUT-A
CAS No. 1591906-37-4
MUT-A ( —— )
Catalog No. M12273 CAS No. 1591906-37-4
MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMUT-A
-
NoteResearch use only, not for human use.
-
Brief DescriptionMUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
-
DescriptionMUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively; interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM; inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM; impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
-
Synonyms——
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1591906-37-4
-
Formula Weight413.58
-
Molecular FormulaC24H31NO3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name(S)-2-(tert-butoxy)-2-(4-(4,4-dimethylcyclohex-1-en-1-yl)-2-methyl-5-(pyridin-4-yl)thiophen-3-yl)acetic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Amadori C, et al. Retrovirology. 2017 Nov 9;14(1):50.
molnova catalog
related products
-
Apelin-36 (rat, mous...
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
-
DDX3-IN-16d
A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3).
-
HIV p17 Gag 77-85
HIV p17 Gag (77-85) is an attractive target for molecular intervention, because it is involved in the viral replication cycle at both the pre- and postintegration levels. In the present experiments, we targeted p17 by intracellularly expressing a cDNA encoding an Ab to p17.
