BNM-III-170 ( —— )

Catalog No. M12870 CAS No. 1859189-54-0

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Product Name

BNM-III-170
Note

Research use only, not for human use.
Brief Description

BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.
Description

BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).
Synonyms

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Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

1859189-54-0
Formula Weight

446.91
Molecular Formula

C21H24ClFN6O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N1-(4-chloro-3-fluorophenyl)-N2-((1R,2R)-2-(guanidinomethyl)-5-((methylamino)methyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363.

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