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E-72
CAS No. 1435055-73-4
E-72 ( G9a inhibitor E72 )
Catalog No. M11850 CAS No. 1435055-73-4
G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameE-72
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NoteResearch use only, not for human use.
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Brief DescriptionG9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM.
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DescriptionG9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2; reactivates K-ras-mediated epigenetic silencing of the proapoptotic Fas gene in NIH 3T3 cells, with much reduced cell cytotoxicity compared with BIX-01294.
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SynonymsG9a inhibitor E72
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number1435055-73-4
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Formula Weight544.79
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Molecular FormulaC29H52N8O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name7-((5-aminopentyl)oxy)-N4-(1-(5-aminopentyl)piperidin-4-yl)-N2-(3-(dimethylamino)propyl)-6-methoxyquinazoline-2,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chang Y, et al. J Mol Biol. 2010 Jul 2;400(1):1-7.
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