UNC0321

Research use only, not for human use.

A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.

A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays; dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4 uM); but lacks sufficient cellular potency.

Western Blot AnalysisCell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Reduced glucose induced expression of Cleared Caspase3 and Bax.Relieved the inhibition of glucose on Bcl-2, Caspase3, p-AKT, p-mTOR and p70 expression.Promoted proliferation and inhibited apoptosis by inhibiting Rab4. Apoptosis Analysis Cell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Inhibited glucose induced apoptosis.Cell Proliferation Assay Cell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Relieved the inhibition of glucose on HUVEC proliferation.

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UNC 0321 | UNC-0321

Chromatin/Epigenetic

HMTase

HMTase

Other Indications

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1238673-32-9

515.6913

C27H45N7O3

>98% (HPLC)

DMSO: ≥ 31 mg/mL

CN1CCC(NC2=C3C=C(OC)C(OCCOCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1

4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-

(-20℃)

With Ice Pack

≥ 2 years