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UNC0321
CAS No. 1238673-32-9
UNC0321 ( UNC 0321;UNC-0321 )
Catalog No. M10957 CAS No. 1238673-32-9
A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | Get Quote |
|
| 5MG | 85 | Get Quote |
|
| 10MG | 132 | Get Quote |
|
| 25MG | 303 | Get Quote |
|
| 50MG | 480 | Get Quote |
|
| 100MG | 692 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUNC0321
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.
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DescriptionA highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays; dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4 uM); but lacks sufficient cellular potency.
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SynonymsUNC 0321;UNC-0321
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1238673-32-9
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Formula Weight515.69
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Molecular FormulaC27H45N7O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESCN1CCC(NC2=C3C=C(OC)C(OCCOCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1
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Chemical Name4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57.
2. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.
2. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.
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