EBI-2511 ( EBI2511 )

Catalog No. M13319 CAS No. 2098546-05-3

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Product Name

EBI-2511
Note

Research use only, not for human use.
Brief Description

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G.
Description

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G; significantly reduces cellular H3K27me3 levels in a dose-dependent with IC50 of 8 nM in Pfeffier cell line, IC50 of 55 nM against WSU-DLCL2; dose-dependently inhibits tumor growth at 10-100 mg/kg, po., shows a superior anti-tumor efficacy to EPZ-6438 in Pfeiffer Xenograft mouse model.
Synonyms

EBI2511
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

2098546-05-3
Formula Weight

576.78
Molecular Formula

C34H48N4O4
Purity

>98% (HPLC)
Solubility

DMSO : 5 mg/mL 8.67 mM
SMILES

O=C(C1=C2C=C(C3CCN(C(C)C)CC3)OC2=CC(N(CC)C4CCOCC4)=C1CC)NCC5=C(C)C=C(C)NC5=O
Chemical Name

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide

1. Lu B, et al. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102.

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