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Dynein2-IN-37
CAS No. 1823133-56-7
Dynein2-IN-37( Ciliobrevin analog 37 )
Catalog No. M12813 CAS No. 1823133-56-7
Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDynein2-IN-37
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NoteResearch use only, not for human use.
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Brief DescriptionDynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM.
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DescriptionDynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM); directly targets the heavy chains of both dynein isoforms and explore the structure-activity landscape of these inhibitors in vitro and in cells; inhibits retrograde ciliary GLI2 transport more strongly than ciliobrevin A, effectively disrupts Hedgehog signaling, intraflagellar transport, and ciliogenesis.
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In Vitro——
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In Vivo——
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SynonymsCiliobrevin analog 37
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetDynein
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RecptorDynein
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Research Area——
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Indication——
Chemical Information
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CAS Number1823133-56-7
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Formula Weight478.329
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Molecular FormulaC25H17Cl2N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-(2,4-dichlorophenyl)-2-(7-(4-methylbenzyloxy)-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-oxopropanenitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60.
molnova catalog
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