Dynarrestin( Dynarrestin )

Catalog No. M13550 CAS No. 2222768-84-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dynarrestin
Note

Research use only, not for human use.
Brief Description

Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis.
Description

Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis; rapidly and reversibly inhibits endosome movement in living cells and perturbs mitosis by inducing spindle misorientation and pseudoprometaphase delay; reversibly inhibits cytoplasmic dynein 2-dependent intraflagellar transport (IFT) of the cargo IFT88 and flux of Smo within cilia without interfering with ciliogenesis and suppresses Hh-dependent proliferation of neuronal precursors and tumor cells.
In Vitro

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In Vivo

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Synonyms

Dynarrestin
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Dynein
Recptor

Dynein
Research Area

——
Indication

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CAS Number

2222768-84-3
Formula Weight

431.502
Molecular Formula

C22H23F2N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (193.12 mM)
SMILES

O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=CC=C(F)C=C3F)S1)OCC
Chemical Name

ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate

1. H?ing S, et al. Cell Chem Biol. 2018 Jan 26. pii: S2451-9456(17)30463-4.

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