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DprE1-IN-1
CAS No. 1494675-86-3
DprE1-IN-1 ( TBA-7371; TBA 7371; TBA7371 )
Catalog No. M17323 CAS No. 1494675-86-3
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 27 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 61 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 317 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDprE1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionDprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
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DescriptionTBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC50 value of 10 nM. It also inhibits PDE6 with an IC50 value of 4 μM.1 AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12 μM and demonstrates efficacy in a rodent model of tuberculosis.
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SynonymsTBA-7371; TBA 7371; TBA7371
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PathwayAngiogenesis
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TargetCDK
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RecptorDprE1
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Research AreaInfection|Inflammation/Immunology
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Indication——
Chemical Information
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CAS Number1494675-86-3
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Formula Weight355.39
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Molecular FormulaC18H21N5O3
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Purity98%
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SolubilityDMSO : 11 mg/mL. 30.95 mM;
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SMILESCc1cc2c(c(cn2Cc2c(c(ncn2)OC)C)C(=O)NCCO)nc1
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Chemical NameN-(2-hydroxyethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shirude PS, et al. J Med Chem. 2014 Jul 10;57(13):5728-37.
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