DprE1-IN-1( TBA-7371 | TBA 7371 | TBA7371 )

Catalog No. M17323 CAS No. 1494675-86-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DprE1-IN-1
Note

Research use only, not for human use.
Brief Description

DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
Description

TBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC50 value of 10 nM. It also inhibits PDE6 with an IC50 value of 4 μM.1 AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12 μM and demonstrates efficacy in a rodent model of tuberculosis.
In Vitro

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In Vivo

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Synonyms

TBA-7371 | TBA 7371 | TBA7371
Pathway

Angiogenesis
Target

CDK
Recptor

DprE1
Research Area

Infection|Inflammation/Immunology
Indication

——

CAS Number

1494675-86-3
Formula Weight

355.39
Molecular Formula

C18H21N5O3
Purity

>98% (HPLC)
Solubility

DMSO : 11 mg/mL. 30.95 mM;
SMILES

Cc1cc2c(c(cn2Cc2c(c(ncn2)OC)C)C(=O)NCCO)nc1
Chemical Name

N-(2-hydroxyethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

1. Shirude PS, et al. J Med Chem. 2014 Jul 10;57(13):5728-37.

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