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Senexin-A
CAS No. 1366002-50-7
Senexin-A( Senexin A )
Catalog No. M11512 CAS No. 1366002-50-7
A selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
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| 5MG | 104 | In Stock |
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| 10MG | 151 | In Stock |
|
| 25MG | 295 | In Stock |
|
| 50MG | 537 | In Stock |
|
| 100MG | 767 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSenexin-A
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NoteResearch use only, not for human use.
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Brief DescriptionA selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.
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DescriptionA selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively; inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells; suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts and reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin.
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In Vitro——
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In Vivo——
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SynonymsSenexin A
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1366002-50-7
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Formula Weight274.32
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Molecular FormulaC17H14N4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥100 mg/mL
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SMILESN#CC1=CC2=C(NCCC3=CC=CC=C3)N=CN=C2C=C1
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Chemical Name6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Porter DC, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804.
2. McDermott MS, et al. Oncotarget. 2017 Feb 21;8(8):12558-12575.
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