BMS-265246( BMS265246 | BMS-265246 | BMS 265246 )

Catalog No. M15136 CAS No. 582315-72-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-265246
Note

Research use only, not for human use.
Brief Description

BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay.
Description

BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.
In Vitro

RT-PCR Cell Line:Calu-3 cells Concentration:9 nM Incubation Time:24 hours Result:Abrogated the ability of CHI3L1 (chitinase 3-like-1) to stimulate epithelial cells ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases).
In Vivo

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Synonyms

BMS265246 | BMS-265246 | BMS 265246
Pathway

Angiogenesis
Target

CDK
Recptor

CDK1/CyclinB| CDK2/CyclinE| CDK4/CyclinD
Research Area

Cancer
Indication

——

CAS Number

582315-72-8
Formula Weight

345.34
Molecular Formula

C18H17F2N3O2
Purity

>98% (HPLC)
Solubility

DMSO: 20 mg/mL (57.91 mM)
SMILES

O=C(C1=CN=C(NN=C2)C2=C1OCCCC)C3=C(F)C=C(C)C=C3F
Chemical Name

(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone

1.Misra RN, et al. Bioorg Med Chem Lett. 2003, 13(14), 2405-2408.

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