DT2216 ( —— )

Catalog No. M24077 CAS No. 2365172-42-3

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Product Name

DT2216
Note

Research use only, not for human use.
Brief Description

DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).
Description

DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).DT2216 targets bcl-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation.
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis;PROTAC;VHL
Research Area

——
Indication

——

CAS Number

2365172-42-3
Formula Weight

1542.4
Molecular Formula

C77H96ClF3N10O10S4
Purity

>98% (HPLC)
Solubility

H2O : < 0.1 mg/mL (insoluble); DMSO : 25 mg/mL (16.21 mM; Need ultrasonic)
SMILES

CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(C1)CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN7CCN(C(CCCCCC(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(N[C@H](C9=CC=C(C%10=C(N=CS%10)C)C=C9)C)=O)=O)=O)=O)CC7)C=C5)=O)=O)C=C4)CC3
Chemical Name

——

1.Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.

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