CWI1-2 HCL( —— )

Catalog No. M36088 CAS No. 2408590-37-2

CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukemia.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	119	In Stock
5MG	93	In Stock
10MG	148	In Stock
25MG	297	In Stock
50MG	423	In Stock
100MG	600	In Stock
200MG	825	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

CWI1-2 HCL
Note

Research use only, not for human use.
Brief Description

CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukemia.
Description

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.
In Vitro

Apoptosis AnalysisCell Line:MonoMac6, MOLM13Concentration:0-1 μMIncubation Time:24 hResult:Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

2408590-37-2
Formula Weight

556.23
Molecular Formula

C22H18Cl4N6O3
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=CC=C(Cl)C=C1/C=N\N/C(N/N=C/C2=CC(Cl)=CC=C2O)=N/N=C/C3=CC(Cl)=CC=C3O.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.?

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