Curzerene

Research use only, not for human use.

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.(In Vitro):Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively.Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells.Curzerene(0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose.Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells.Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.

Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively.Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells.Curzerene(0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose.Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells.Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells. Cell Viability Assay Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.Apoptosis Analysis Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:48 hours Result:Induced apoptosis of the cells in a dose-dependent manner.Apoptosis Analysis Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:48 hours Result:Induced G2/M cell cycle arrest of SPC A1 cells.RT-PCRCell Line:SPC-A1 cells Concentration:6.25 μM, 25 μM, 100 μM Incubation Time:48 hours Result:Decreased GSTA1 mRNA expression.

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Apoptosis

Apoptosis

Apoptosis

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17910-09-7

216.32

C15H20O

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1155.70 mM)

C[C@](Cc1c(C2)c(C)co1)([C@H]2C(C)=C)C=C

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(-20℃)

With Ice Pack

≥ 2 years