Curzerene

CAS No. 17910-09-7

Curzerene( —— )

Catalog No. M21444 CAS No. 17910-09-7

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Curzerene
  • Note
    Research use only, not for human use.
  • Brief Description
    Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.
  • Description
    Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.(In Vitro):Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively.Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells.Curzerene(0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose.Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells.Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.
  • In Vitro
    Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively.Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells.Curzerene(0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose.Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells.Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells. Cell Viability Assay Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.Apoptosis Analysis Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:48 hours Result:Induced apoptosis of the cells in a dose-dependent manner.Apoptosis Analysis Cell Line:SPC-A1 cells Concentration:0 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:48 hours Result:Induced G2/M cell cycle arrest of SPC A1 cells.RT-PCRCell Line:SPC-A1 cells Concentration:6.25 μM, 25 μM, 100 μM Incubation Time:48 hours Result:Decreased GSTA1 mRNA expression.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    17910-09-7
  • Formula Weight
    216.32
  • Molecular Formula
    C15H20O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1155.70 mM)
  • SMILES
    C[C@](Cc1c(C2)c(C)co1)([C@H]2C(C)=C)C=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang Y et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.
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