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AGN 192870
CAS No. 166977-57-7
AGN 192870( —— )
Catalog No. M35574 CAS No. 166977-57-7
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 104 | In Stock |
|
| 10MG | 164 | In Stock |
|
| 25MG | 328 | In Stock |
|
| 50MG | 516 | In Stock |
|
| 100MG | 833 | In Stock |
|
| 200MG | 1125 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAGN 192870
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NoteResearch use only, not for human use.
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Brief DescriptionAGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
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DescriptionAGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism. AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Retinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number166977-57-7
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Formula Weight378.46
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Molecular FormulaC27H22O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 6.25 mg/mL (16.51 mM; Ultrasonic (<60°C)
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SMILESCC1(C)C=2C(C(=CC1)C3=CC=CC=C3)=CC(C#CC4=CC=C(C(O)=O)C=C4)=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Klein ES, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem. 1996;271(37):22692-22696. ?
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