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VPC-70063
CAS No. 13571-44-3
VPC-70063( Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- )
Catalog No. M28492 CAS No. 13571-44-3
VPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 194 | Get Quote |
|
| 10MG | 267 | Get Quote |
|
| 25MG | 498 | Get Quote |
|
| 50MG | 710 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 500MG | 1962 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVPC-70063
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NoteResearch use only, not for human use.
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Brief DescriptionVPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
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DescriptionVPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.(In Vitro):VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner.
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In VitroVPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%.VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP.VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner.Western Blot Analysis Cell Line:LNCaP cells Concentration:6.25 μM, 12.5 μM and 25 μM Incubation Time:48 h Result:Induced PARP cleavage.
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In Vivo——
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SynonymsThiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
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PathwayApoptosis
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TargetApoptosis
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RecptorP2X3
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Research Area——
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Indication——
Chemical Information
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CAS Number13571-44-3
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Formula Weight378.33
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Molecular FormulaC16H12F6N2S
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)NC(=S)NCC=2C=CC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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