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CCT-251921
CAS No. 1607837-31-9
CCT-251921 ( CCT 251921;CCT251921 )
Catalog No. M12311 CAS No. 1607837-31-9
A potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 210 | Get Quote |
|
| 10MG | 308 | Get Quote |
|
| 25MG | 519 | Get Quote |
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| 50MG | 744 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCCT-251921
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.
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DescriptionA potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively; reduces STAT1 Ser727 phosphorylation, inhibits tunor growth of APC-mutant SW620 human colorectal carcinoma xenograft mode, has pharmacokinetic, and physicochemical properties.
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SynonymsCCT 251921;CCT251921
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1607837-31-9
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Formula Weight410.91
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Molecular FormulaC21H23ClN6O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 28 mg/mL. 68.14 mM
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SMILESO=C1NCCC12CCN(C3=C(Cl)C(N)=NC=C3C4=CC5=C(N(C)N=C5)C=C4)CC2
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Chemical Name8-(2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mallinger A, et al. J Med Chem. 2016 Feb 11;59(3):1078-101.
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