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CCT-251921

CAS No. 1607837-31-9

CCT-251921 ( CCT 251921;CCT251921 )

Catalog No. M12311 CAS No. 1607837-31-9

A potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCT-251921
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.
  • Description
    A potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively; reduces STAT1 Ser727 phosphorylation, inhibits tunor growth of APC-mutant SW620 human colorectal carcinoma xenograft mode, has pharmacokinetic, and physicochemical properties.
  • Synonyms
    CCT 251921;CCT251921
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1607837-31-9
  • Formula Weight
    410.91
  • Molecular Formula
    C21H23ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 28 mg/mL. 68.14 mM
  • SMILES
    O=C1NCCC12CCN(C3=C(Cl)C(N)=NC=C3C4=CC5=C(N(C)N=C5)C=C4)CC2
  • Chemical Name
    8-(2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mallinger A, et al. J Med Chem. 2016 Feb 11;59(3):1078-101.
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