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CAN-508

CAS No. 140651-18-9

CAN-508 ( CAN508 )

Catalog No. M11707 CAS No. 140651-18-9

CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CAN-508
  • Note
    Research use only, not for human use.
  • Brief Description
    CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).
  • Description
    CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM); reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays; decreases phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II, inhibits mRNA synthesis, and induces the tumor suppressor protein p53.
  • Synonyms
    CAN508
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    140651-18-9
  • Formula Weight
    218.22
  • Molecular Formula
    C9H10N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=CC=C(/N=N/C2=C(N)NN=C2N)C=C1
  • Chemical Name
    4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Krystof V, et al. J Med Chem. 2006 Nov 2;49(22):6500-9.
2. Krytof V, et al. Eur J Med Chem. 2011 Sep;46(9):4289-94.
3. Tong Z, et al. Oncotarget. 2017 Apr 25;8(17):28696-28710.
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