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CAN-508
CAS No. 140651-18-9
CAN-508 ( CAN508 )
Catalog No. M11707 CAS No. 140651-18-9
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | Get Quote |
|
| 10MG | 124 | Get Quote |
|
| 25MG | 210 | Get Quote |
|
| 50MG | 311 | Get Quote |
|
| 100MG | 462 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCAN-508
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NoteResearch use only, not for human use.
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Brief DescriptionCAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).
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DescriptionCAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM); reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays; decreases phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II, inhibits mRNA synthesis, and induces the tumor suppressor protein p53.
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SynonymsCAN508
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number140651-18-9
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Formula Weight218.22
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Molecular FormulaC9H10N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESOC1=CC=C(/N=N/C2=C(N)NN=C2N)C=C1
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Chemical Name4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Krystof V, et al. J Med Chem. 2006 Nov 2;49(22):6500-9.
2. Krytof V, et al. Eur J Med Chem. 2011 Sep;46(9):4289-94.
3. Tong Z, et al. Oncotarget. 2017 Apr 25;8(17):28696-28710.
2. Krytof V, et al. Eur J Med Chem. 2011 Sep;46(9):4289-94.
3. Tong Z, et al. Oncotarget. 2017 Apr 25;8(17):28696-28710.
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