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iCDK9
CAS No. 1263369-28-3
iCDK9 ( i-CDK9 )
Catalog No. M11102 CAS No. 1263369-28-3
iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 177 | Get Quote |
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| 10MG | 266 | Get Quote |
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| 25MG | 461 | Get Quote |
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| 50MG | 669 | Get Quote |
|
| 100MG | 945 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameiCDK9
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NoteResearch use only, not for human use.
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Brief DescriptioniCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
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DescriptioniCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC; potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing; efficiently suppresses P-TEFb's phosphorylation of the Pol II CTD and the DSIF subunit SPT5 and causes widespread Pol II pausing at gene promoters, enhances the MYC mRNA production but not protein stability.
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Synonymsi-CDK9
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1263369-28-3
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Formula Weight425.94
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Molecular FormulaC23H25ClFN5
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 117.39 mM
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SMILESN[C@@H]1CC[C@H](NC2=NC=C(Cl)C(C3=NC(NCC4=CC(F)=CC=C4)=CC=C3)=C2)CC1
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Chemical NameN2'-((1r,4r)-4-aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu H, et al. Elife. 2015 Jun 17;4:e06535. doi: 10.7554/eLife.06535.
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