iCDK9 ( i-CDK9 )

Catalog No. M11102 CAS No. 1263369-28-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

iCDK9
Note

Research use only, not for human use.
Brief Description

iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
Description

iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC; potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing; efficiently suppresses P-TEFb's phosphorylation of the Pol II CTD and the DSIF subunit SPT5 and causes widespread Pol II pausing at gene promoters, enhances the MYC mRNA production but not protein stability.
Synonyms

i-CDK9
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Infection
Indication

——

CAS Number

1263369-28-3
Formula Weight

425.94
Molecular Formula

C23H25ClFN5
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 117.39 mM
SMILES

N[C@@H]1CC[C@H](NC2=NC=C(Cl)C(C3=NC(NCC4=CC(F)=CC=C4)=CC=C3)=C2)CC1
Chemical Name

N2'-((1r,4r)-4-aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine

1. Lu H, et al. Elife. 2015 Jun 17;4:e06535. doi: 10.7554/eLife.06535.

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