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Bupivacaine
CAS No. 38396-39-3
Bupivacaine( —— )
Catalog No. M32727 CAS No. 38396-39-3
Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 30 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBupivacaine
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NoteResearch use only, not for human use.
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Brief DescriptionBupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.
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DescriptionBupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
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In VitroCell Viability Assay Cell Line:HEK 293 cells transfected with the SK2 gene (transfected cells were named SK2 cells) Concentration:10, 100, 1000 μM Incubation Time:Result:The IC50 value was 16.5 μM.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel | NMDAR
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Research Area——
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Indication——
Chemical Information
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CAS Number38396-39-3
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Formula Weight288.43
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Molecular FormulaC18H28N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (346.70 mM; Ultrasonic )
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SMILESCCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.?
2. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.?
3. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.?
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