SM-6586( —— )

Catalog No. M33501 CAS No. 103898-38-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SM-6586
Note

Research use only, not for human use.
Brief Description

SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular disease and hypertension, among other diseases.
Description

SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
In Vitro

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In Vivo

In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group.
Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel | Na+/Ca2+ Exchanger
Research Area

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Indication

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CAS Number

103898-38-0
Formula Weight

489.52
Molecular Formula

C26H27N5O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(C)NC(C)=C(C1C2=CC([N+]([O-])=O)=CC=C2)C3=NC(CN(CC4=CC=CC=C4)C)=NO3)OC
Chemical Name

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1. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.?

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