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Bupivacaine

CAS No. 38396-39-3

Bupivacaine( —— )

Catalog No. M32727 CAS No. 38396-39-3

Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
50MG 31 In Stock
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Biological Information

  • Product Name
    Bupivacaine
  • Note
    Research use only, not for human use.
  • Brief Description
    Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.
  • Description
    Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
  • In Vitro
    Cell Viability Assay Cell Line:HEK 293 cells transfected with the SK2 gene (transfected cells were named SK2 cells) Concentration:10, 100, 1000 μM Incubation Time:Result:The IC50 value was 16.5 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel | NMDAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    38396-39-3
  • Formula Weight
    288.43
  • Molecular Formula
    C18H28N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (346.70 mM; Ultrasonic )
  • SMILES
    CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.? 2. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.? 3. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.?
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