Bictegravir
CAS No. 1611493-60-7
Bictegravir ( GS 9883 )
Catalog No. M12333 CAS No. 1611493-60-7
Bictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 55 | In Stock |
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10MG | 87 | In Stock |
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25MG | 176 | In Stock |
|
50MG | 295 | In Stock |
|
100MG | 444 | In Stock |
|
500MG | 1008 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameBictegravir
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NoteResearch use only, not for human use.
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Brief DescriptionBictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.
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DescriptionBictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM; exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes with EC50 of 1.5-2.4 nM, with minimal cytotoxicity; exhibits synergistic in vitro antiviral effects in pairwise combinations with tenofovir alafenamide, emtricitabine, or darunavir and maintains potent antiviral activity against HIV-1 variants.HIV Infection Phase 3 Clinical
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SynonymsGS 9883
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV-1integrase
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number1611493-60-7
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Formula Weight449.39
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Molecular FormulaC21H18F3N3O5
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Purity>98% (HPLC)
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SolubilityDMSO: 80 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESC1CC2CC1N3C(O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F
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Chemical Name(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsiang M, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.
2. Gallant JE, et al. J Acquir Immune Defic Syndr. 2017 May 1;75(1):61-66.
3. Hassounah SA, et al. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01695-17.
2. Gallant JE, et al. J Acquir Immune Defic Syndr. 2017 May 1;75(1):61-66.
3. Hassounah SA, et al. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01695-17.
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