Bictegravir

CAS No. 1611493-60-7

Bictegravir ( GS 9883 )

Catalog No. M12333 CAS No. 1611493-60-7

Bictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 55 In Stock
10MG 87 In Stock
25MG 176 In Stock
50MG 295 In Stock
100MG 444 In Stock
500MG 1008 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Bictegravir
  • Note
    Research use only, not for human use.
  • Brief Description
    Bictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.
  • Description
    Bictegravir (GS 9883) is a novel potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM; exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes with EC50 of 1.5-2.4 nM, with minimal cytotoxicity; exhibits synergistic in vitro antiviral effects in pairwise combinations with tenofovir alafenamide, emtricitabine, or darunavir and maintains potent antiviral activity against HIV-1 variants.HIV Infection Phase 3 Clinical
  • Synonyms
    GS 9883
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV-1integrase
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1611493-60-7
  • Formula Weight
    449.39
  • Molecular Formula
    C21H18F3N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 80 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    C1CC2CC1N3C(O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F
  • Chemical Name
    (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsiang M, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.
2. Gallant JE, et al. J Acquir Immune Defic Syndr. 2017 May 1;75(1):61-66.
3. Hassounah SA, et al. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01695-17.
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