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BRD-73954

CAS No. 1440209-96-0

BRD-73954 ( BRD73954 )

Catalog No. M11867 CAS No. 1440209-96-0

The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	45	In Stock
5MG	81	In Stock
10MG	136	In Stock
25MG	273	In Stock
50MG	412	In Stock
100MG	606	In Stock
500MG	1287	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BRD-73954
Note

Research use only, not for human use.
Brief Description

The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM.
Description

The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM; show no significant inhibition for other HDAC isoforms (IC50>9 uM); robustly increase in α-tubulin acetylation, has no change in the acetylation state of H3 in Hela cells.
Synonyms

BRD73954
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC2;HDAC4;HDAC6;HDAC8
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1440209-96-0
Formula Weight

284.31
Molecular Formula

C16H16N2O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 35 mg/mL
SMILES

C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO
Chemical Name

1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Olson DE, et al. J Med Chem. 2013 Jun 13;56(11):4816-20.

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