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PCI-24781
CAS No. 783355-60-2
PCI-24781 ( CRA 024781;CRA 24781;PCI 24781;Abexinostat )
Catalog No. M15956 CAS No. 783355-60-2
A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 99 | In Stock |
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| 25MG | 171 | In Stock |
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| 50MG | 309 | In Stock |
|
| 100MG | 485 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePCI-24781
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NoteResearch use only, not for human use.
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Brief DescriptionA broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.
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DescriptionA broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM; also inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range; causes the accumulation of acetylated histone and acetylated tubulin in tumor cell lines; decreases RAD51 expression and inhibits homologous recombination.Blood Cancer Phase 2 Clinical
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SynonymsCRA 024781;CRA 24781;PCI 24781;Abexinostat
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC10;HDAC2;HDAC3/SMRT;HDAC6
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number783355-60-2
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Formula Weight397.42
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Molecular FormulaC21H23N3O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C(O1)=C(CN(C)C)C2=C1C=CC=C2)NCCOC3=CC=C(C(NO)=O)C=C3
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Chemical Name2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Buggy JJ, et al. Mol Cancer Ther. 2006 May;5(5):1309-17.
2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.
2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.
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