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Home - Products - Cell Cycle/DNA Damage - HDAC - PCI-24781

PCI-24781

CAS No. 783355-60-2

PCI-24781 ( CRA 024781;CRA 24781;PCI 24781;Abexinostat )

Catalog No. M15956 CAS No. 783355-60-2

A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 65 In Stock
10MG 99 In Stock
25MG 171 In Stock
50MG 309 In Stock
100MG 485 In Stock
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Biological Information

  • Product Name
    PCI-24781
  • Note
    Research use only, not for human use.
  • Brief Description
    A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.
  • Description
    A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM; also inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range; causes the accumulation of acetylated histone and acetylated tubulin in tumor cell lines; decreases RAD51 expression and inhibits homologous recombination.Blood Cancer Phase 2 Clinical
  • Synonyms
    CRA 024781;CRA 24781;PCI 24781;Abexinostat
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC10;HDAC2;HDAC3/SMRT;HDAC6
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    783355-60-2
  • Formula Weight
    397.42
  • Molecular Formula
    C21H23N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C(O1)=C(CN(C)C)C2=C1C=CC=C2)NCCOC3=CC=C(C(NO)=O)C=C3
  • Chemical Name
    2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Buggy JJ, et al. Mol Cancer Ther. 2006 May;5(5):1309-17.
2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.
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