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HDACi-4b
CAS No. 537034-15-4
HDACi-4b( NKL22 | NKL-22 )
Catalog No. M14906 CAS No. 537034-15-4
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 87 | In Stock |
|
| 50MG | 165 | In Stock |
|
| 100MG | 318 | In Stock |
|
| 500MG | 752 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHDACi-4b
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NoteResearch use only, not for human use.
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Brief DescriptionA benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
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DescriptionA benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12); significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
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In Vitro——
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In Vivo——
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SynonymsNKL22 | NKL-22
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number537034-15-4
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Formula Weight325.4048
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Molecular FormulaC19H23N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESO=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
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Chemical NameHeptanediamide, N1-(2-aminophenyl)-N7-phenyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
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