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Home - Products - Cell Cycle/DNA Damage - HDAC - HDACi-4b

HDACi-4b

CAS No. 537034-15-4

HDACi-4b ( NKL22;NKL-22 )

Catalog No. M14906 CAS No. 537034-15-4

A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 27 In Stock
10MG 42 In Stock
25MG 87 In Stock
50MG 165 In Stock
100MG 318 In Stock
500MG 752 In Stock
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Biological Information

  • Product Name
    HDACi-4b
  • Note
    Research use only, not for human use.
  • Brief Description
    A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
  • Description
    A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12); significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
  • Synonyms
    NKL22;NKL-22
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    537034-15-4
  • Formula Weight
    325.40
  • Molecular Formula
    C19H23N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
  • Chemical Name
    Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
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