ACY-241 ( Citarinostat )

Catalog No. M11281 CAS No. 1316215-12-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

ACY-241
Note

Research use only, not for human use.
Brief Description

ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity.
Description

ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
Synonyms

Citarinostat
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Research Area

Cancer
Indication

——

CAS Number

1316215-12-9
Formula Weight

467.95
Molecular Formula

C24H26ClN5O3
Purity

>98%(HPLC)
Solubility

Soluble in DMSO
SMILES

ClC1=CC=CC=C1N(C2=CC=CC=C2)C3=NC=C(C=N3)C(NCCCCCCC(NO)=O)=O
Chemical Name

2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

1. Ruben N, et al. Blood. 2015, 126:3040;

Calculator

molnova catalog