BMS-433796 ( BMS433796; BMS-433796; BMS 433796. )

Catalog No. M16690 CAS No. 935525-13-6

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Product Name

BMS-433796
Note

Research use only, not for human use.
Brief Description

A potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
Description

A potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM; exhibits Abeta lowering activity in a transgenic mouse model of Alzheimer's disease with acceptable pharmacodynamic and pharmacokinetic profile..Alzheimer's Disease Discontinued
Synonyms

BMS433796; BMS-433796; BMS 433796.
Pathway

Wnt/Notch/Hedgehog
Target

γ-secretase
Recptor

γ-secretase
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

935525-13-6
Formula Weight

430.40
Molecular Formula

C21H20F2N4O4
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

C[C@H](NC([C@H](C1=CC(F)=CC(F)=C1)O)=O)C(N[C@H]2C3=CC=CC=C3C=NN(C)C2=O)=O
Chemical Name

Benzeneacetamide, N-[(1S)-2-[[(5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-

1. Prasad CV, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11.
2. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.

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