BI-3663 ( BI3663;BI 3663 )

Catalog No. M16957 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI-3663
Note

Research use only, not for human use.
Brief Description

BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines.
Description

BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines; degraded PTK2 potently (DC50 = 27 nM) with a maximally obtainable degradation at the chosen experimental conditions of 95% (Dmax) in human lung adenocarcinoma cell line A549 after 16 hours treatment.
Synonyms

BI3663;BI 3663
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

--
Formula Weight

917.85
Molecular Formula

C44H42F3N7O12
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

N-(2-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)ethyl)-3-methoxy-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

1. Popow J, et al. J Med Chem. 2019 Feb 9. doi: 10.1021/acs.jmedchem.8b01826.

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