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CDK9-PROTAC

CAS No. 2118356-96-8

CDK9-PROTAC( CDK9PROTAC | CDK9 PROTAC | CDK9-PROTAC )

Catalog No. M13368 CAS No. 2118356-96-8

CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CDK9-PROTAC
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.
  • Description
    CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9; selectively degrades CDK9 while sparing other CDK family members in HCT116 cells.
  • In Vitro
    PROTAC CDK9 Degrader-1 (Compound 3; 2.5-20 μM; 6 hours) degrades CDK9 in a dose dependent manner in HCT116 cells.Western Blot Analysis Cell Line:HCT116 cells Concentration:2.5, 5, 10, and 20μM Incubation Time:6 hours Result:Degraded CDK9 in a dose dependent manner.
  • In Vivo
    ——
  • Synonyms
    CDK9PROTAC | CDK9 PROTAC | CDK9-PROTAC
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2118356-96-8
  • Formula Weight
    613.671
  • Molecular Formula
    C33H35N5O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 104 mg/mL 169.47 mM
  • SMILES
    O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(OCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)C=C3
  • Chemical Name
    N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Robb CM, et al. Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580.
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